Rebecca Switzer

Educational Background

• B.S., Indiana State University
• Ph.D., University of Michigan

Scholarly Interests

• Biochemistry
• Enzyme kinetics and mechanisms
• Enzyme inhibition

Lab website

Selected Publications

(*Bucknell undergraduate student)

Switzer, R. L., Hartman, Z. J.*, Hewett, G. R.*, and Carroll, C. F.* (2023) “Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1” DNA 3, 119-133. DOI: 10.3390/dna3030010

Switzer, R. L., Ward, K. A.*, and Medrano, J.* (2022) “Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors” J. Vis. Exp. 186, e62949. DOI: 10.3791/62949

Palfey, B. A. and Switzer, R. L. (2022) Kinetics of Enzyme Catalysis; American Chemical Society. DOI: 10.1021/acsinfocus.7e5015

Dolen, E. K.*, McGinnis, J. H.*, Tavory, R. N.*, Weiss, J. A.*, and Switzer, R. L. (2019) “Disease-associated mutations G589A and V590F relieve RFTS-mediated autoinhibition of DNA methyltransferase 1” Biochemistry 58, 5151-5159. DOI: 10.1021/acs.biochem.9b00749

Switzer, R. L., Medrano, J.*, Reedel, D. A.*, and Weiss, J.* (2019) “Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors” PLoS ONE 14, e0219830. DOI: 10.1371/journal.pone.0219830